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Inflammation also modulates synaptic function through signaling pathways such as BDNFTwo-pore-domain potassium channel TREK-1 (TREK-1) and Phosphoinositide 3-kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR)

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doi: 10.1007/S11154-014-9289-5 27 KalinderiKPapaliagkasVFidaniL

These ergogenic effects likely reflect nitric oxide-mediated perfusion and faster ammonia clearance, which support both aerobic capacity and recovery